Purwaniati Purwaniati, Aiyi Asnawi


Corona virus desease 2019 (COVID-19) yang disebabkan Severe acute respiratory syndrome Corona Virus 2 (SARS-CoV-2) telah menjadi wabah global. Hingga saat belum ada obat atau vaksin untuk terapi COVID-19 ini. Upaya penemuan obat baru atau pengujian terhadap obat yang telah ada mendesak untuk dilakukan. Penentuan target kerja obat COVID-19 yang tepat menjadi tantangan tersendiri, karena sebagai virus baru strukturnya belum diketahui secara jelas. Dalam kesempatan ini, kami melakukan sistematik review untuk dapat mengidentifikasi molekul-molekul yang dapat menjadi target kerja obat anti COVID-19. Review ini diawali dengan penelusuran pustaka pada database Pubmed dengan menggunakan kata kunci “SARS-CoV-2 drug target”. Main protease (Mpro), angiotensin converting enzyme 2 (ACE2), protein spike dan RNA-dependent RNA polymerase (RdRp) merupakan protein target yang paling banyak digunakan dalam penelitian.

Kata Kunci

Target Kerja SARS-CoV-2, COVID-19, Virus Corona

Teks Lengkap:

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